PAD™ Cream Technology
For patients with chronic dermatologic conditions
A breakthrough in topical therapies
Welcome to PAD™ Technology
– designed to make treatment feel as good as it works
The skin ecosystem is amazingly powerful when it is in a state of balance, let PAD™ Cream Technology restore it. Our skin is our largest organ and an integrated part of our appearance. Healthy skin is a formidable barrier to prevent infections and defend the body against toxic compounds.
Balance is maintained by several biologic mechanisms that we should not attempt to control but rather nourish to restore normal conditions when needed. Optimal conditions for the skin ecosystem are maintained by eating healthy food, physical exercise, positive thinking, proper sleep and avoiding exposure to toxic compounds.
However, sometimes genetic disorders or certain life-style conditions negatively influence the normal symbiosis in the body or result in lack of essential building blocks for healthy skin. In such cases, help to restore the normal skin ecosystem is needed. PAD™ creams can help with multiple different areas of your skin.
A topical product that is applied on the skin frequently must be carefully designed and formulated to re-activate the forces of the skin ecosystem and be so pleasant to use in daily routines that you would want to use it every day.
More than a decade ago, we set out to develop a new class of cream that would be both powerful and pure. Now it is here. Meet PADTM Technology based creams from MC2 Therapeutics.
What is PAD™ Technology?
More than a decade ago, we set out to find a way to mix oil and water into creams and lotions that would cause the least interference with the fragile skin ecosystem. The result was PAD™ Technology – a new method of mixing oil and water into creams – a new class of cream that is powerful and yet pure.
PAD™ Technology enables creams to be made with well characterized ingredients in the quantities needed. Nothing else.
PAD™ based creams are purer than any other creams and yet powerful enough to deliver essential ingredients through the skin barrier to release their full potential.
Traditionally, oil and water are combined with emulsifiers to bind them together. When high quantities of emulsifiers are used, it can cause a “wash out” of the skin’s own protective substances, such as the multilamellar lipids, when rinsed. Too much emulsifier can also cause stinging or burning in fissured or broken skin.
That’s why conventional creams and lotions may be less tolerated by patients with skin problems like eczema and psoriasis, or for patients with skin infections, that may make sensitive skin more prone to irritants as well as harmful microorganisms.
PAD™ Technology enables the mixing of oil and water into a cream using just a fraction of the emulsifier required in conventional creams and lotions. No wax is used. PAD™ Technology makes creams that patients can conveniently use in daily routines because they’re not sticky or uncomfortable.
The PAD based cream is so robust that it can be mixed with a high concentration (>80%) of alcohol, thereby enabling the world’s first cream/lotion based hand sanitizer (Biomee™ hand sanitizer lotion).
PAD™ Technology based cream is used in the development of a new range of topical prescription drugs for chronic inflammatory conditions. PAD™ based formulations are excellent for solubilizing active compounds, stabilizing and providing delivery of the active molecules to the target tissue, and releasing the full potential of the medication.
Application in a novel skin care line for chronic dry, itchy and sensitive skin
PAD™ Technology is the foundation of a novel skin care line under development for launch in Q4 2020.
Application in prescription drugs PAD™
Technology based cream is used by MC2 Therapeutics in the development of a new range of topical prescription drugs for chronic inflammatory conditions. The first PAD™ based drug for psoriasis was approved on 20th July 2020. PAD™ based formulations are excellent for solubilizing active compounds, stabilizing and providing delivery of the active molecules to the target tissue, and releasing the full potential of the medication.
How does this topical cream work?
PAD™ Technology allows carefully selected surfactants to organize around the oil droplet, creating a strong shell structure.
Take a look at the unique physical/chemical properties of PAD™ Technology:
Robust oil droplet:
The internal oil phase is stabilized by encapsulation in a robust aqueous film, with a structure and composition that is very different from conventional emulsions. The robust oil droplet enables use of ingredients (e.g., solvents and various oils) in quantities and combinations that optimize solubility of active ingredients and penetration through the skin.
Very low amounts of surfactants:
The PAD™ droplets are made with much lower (>10 times lower) amounts of surfactants than conventional emulsions. This is due to the inherent stability of the PAD™ oil droplet that eliminates the need of a large excess of surfactant in the external phase compared with conventional emulsions.
Oil-in-water:
The oil content is lower in PAD™ formulations than in corresponding ointment or liquid oil formulations that have no water.
About MC2 Therapeutics
MC2 Therapeutics is a privately held commercial-stage pharmaceutical company committed to introducing a new standard of topical therapies using PAD™ Technology.
Our goal was to come up with a base formulation that creates the least interference with the fragile skin ecosystem. Once we did that, we could tailor it to specific skin conditions using carefully selected ingredients – all focused on giving patients a treatment option that’s actually pleasant to use.
The result was PAD™ Technology.
Patients with chronic inflammatory skin conditions and/or dry, itchy and sensitive skin can benefit from this enhanced formulation technology that releases the full potential of carefully selected ingredients in formulations designed for ease of use and convenience in daily routines.